The course "Information Systems in the Hybrid World" is a graduate-level exploration of the dynamic landscape where traditional and digital realms converge to shape the modern business environment. This interdisciplinary course delves into the intricate interplay between technology, data, and organizational processes, providing students with a comprehensive understanding of how information systems are harnessed to drive innovation, efficiency, and strategic decision-making. Through a blend of theoretical insights and practical case studies, participants will gain proficiency in navigating the complexities of hybrid systems, encompassing on-premises and cloud-based solutions, and learn to leverage emerging technologies like edge computing and IoT. With a focus on adaptability, cybersecurity, and ethical considerations, students will emerge from the course equipped to architect and manage Information Systems that thrive in the hybrid world, ensuring sustainable growth and competitive advantage for enterprises.