We are already in a deep process of the fourth industrial revolution, Industry 4.0, which is relevant and touches almost every area of ??our lives. Unlike the previous industrial revolutions, this revolution also brings about a complex change of concept and paradigm and includes additional stages such as digital transformation, a holistic concept at the Eco System level and a high level of customer involvement. This paradigm involves system engineering which is a central part of a broader project management process. In this course we will combine the study of project management approaches and system engineering with the changing and new tools and processes that the fourth industrial revolution brings with it. We will also review the parallel change and adaptation processes and the new skills required of the system engineer.